Phototoxicity Assays
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OECD Test No. 432: In Vitro 3T3 NRU Phototoxicity Test
Test No. 432 is a guideline that describes the In Vitro 3T3 NRU Phototoxicity Test, which is used to evaluate the potential of chemicals or substances to cause phototoxicity, a toxic reaction triggered by exposure to light. The guideline provides instructions for treating 3T3 cells with the test substance, subjecting them to both UVA and visible light exposure, and assessing cell viability. This test helps identify substances that can induce phototoxic effects, providing important information for assessing their potential risks to human health and guiding safety measures for photosensitizing substances
OECD Test No. 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method
Test No. 498 is a guideline that outlines the In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity Test Method. This test is used to assess the potential of chemicals or substances to cause phototoxicity, a toxic reaction triggered by exposure to light, using reconstructed human epidermis models. The guideline provides instructions for exposing the models to the test substance, subjecting them to UVA and visible light exposure, and assessing various endpoints such as tissue viability or cytokine release. This test helps identify substances that can induce phototoxic effects on human skin, providing valuable information for evaluating their potential risks and guiding safety measures for photosensitizing substances.